Luisa M Botella Selected Research

Hereditary Hemorrhagic Telangiectasia

1/2018	Soluble endoglin regulates expression of angiogenesis-related proteins and induction of arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia.
10/2017	Endoglin and alk1 as therapeutic targets for hereditary hemorrhagic telangiectasia.
2/2017	Mutation affecting the proximal promoter of Endoglin as the origin of hereditary hemorrhagic telangiectasia type 1.
4/2016	Endoglin regulates mural cell adhesion in the circulatory system.
3/2016	Mice Lacking Endoglin in Macrophages Show an Impaired Immune Response.
6/2014	Expression of endoglin isoforms in the myeloid lineage and their role during aging and macrophage polarization.
11/2013	Copy number variations in endoglin locus: mapping of large deletions in Spanish families with hereditary hemorrhagic telangiectasia type 1.
9/2013	BMP9 mutations cause a vascular-anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasia.
1/2012	Local sclerotherapy with polydocanol (Aethoxysklerol®) for the treatment of Epistaxis in Rendu-Osler-Weber or Hereditary Hemorrhagic Telangiectasia (HHT): 15 years of experience.
1/2012	Characterization of chicken endoglin, a member of the zona pellucida family of proteins, and its tissue expression.

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Luisa M Botella Research Topics

Disease

17	Hereditary Hemorrhagic Telangiectasia 01/2018 - 11/2002
4	Inflammation (Inflammations) 06/2019 - 01/2013
4	Vascular System Injuries 04/2016 - 12/2002
4	Telangiectasis (Telangiectasia) 01/2016 - 03/2010
4	Vascular Remodeling 01/2013 - 11/2002
3	Hypoxia (Hypoxemia) 01/2021 - 11/2002
3	Arteriovenous Malformations (Arteriovenous Malformation) 01/2018 - 04/2010
3	Epistaxis (Nosebleed) 01/2016 - 03/2010
2	Vascular Diseases (Vascular Disease) 01/2021 - 11/2002
2	Pre-Eclampsia (Preeclampsia) 04/2016 - 06/2014
2	Wounds and Injuries (Trauma) 04/2016 - 03/2006
2	Hemorrhage 01/2016 - 03/2006
2	Neoplasms (Cancer) 06/2014 - 11/2002
1	Cardiovascular Diseases (Cardiovascular Disease) 09/2020
1	Hyperplasia 01/2018
1	Brain Stem Infarctions (Weber Syndrome) 03/2016
1	Communicable Diseases (Infectious Diseases) 03/2016
1	Vascular Malformations 01/2016
1	Liver Failure 05/2011
1	Anemia 05/2011
1	Osteoporosis 03/2010

Drug/Important Bio-Agent (IBA)

20	EndoglinIBA 06/2019 - 11/2002
6	Transforming Growth Factor beta (TGF-beta)IBA 04/2016 - 11/2002
5	Transcription Factors (Transcription Factor)IBA 01/2021 - 11/2002
5	Activin Receptors (Activin Receptor)IBA 04/2016 - 03/2006
2	Proteins (Proteins, Gene)FDA Link 01/2018 - 01/2013
1	RNA (Ribonucleic Acid)IBA 09/2020
1	MicroRNAs (MicroRNA)IBA 09/2020
1	Cell Surface ReceptorsIBA 06/2019
1	Retinaldehyde (Retinal)IBA 01/2018
1	Matrix Metalloproteinases (MMPs)IBA 04/2016
1	IntegrinsIBA 04/2016
1	Metalloproteases (Metalloproteinases)IBA 04/2016
1	bazedoxifeneIBA 01/2016
1	Selective Estrogen Receptor Modulators (SERM)IBA 01/2016
1	ChemokinesIBA 01/2013
1	5' Untranslated Regions (5' UTR)IBA 12/2011
1	Tacrolimus (Prograf)FDA LinkGeneric 05/2011
1	Transforming Growth Factor beta Receptors (TGF beta Receptors)IBA 04/2010
1	Biomarkers (Surrogate Marker)IBA 04/2010
1	Estrogens (Estrogen)FDA Link 03/2010
1	Raloxifene Hydrochloride (Evista)FDA Link 03/2010
1	Erythropoietin FDA Link 02/2004
1	Oxygen (Dioxygen)IBA 02/2004
1	Membrane Glycoproteins (Membrane Glycoprotein)IBA 12/2002
1	Membrane Proteins (Integral Membrane Proteins)IBA 11/2002
1	Smad Proteins (Mothers Against Decapentaplegic Homolog)IBA 11/2002
1	ElementsIBA 11/2002

Therapy/Procedure

2	Therapeutics 01/2021 - 03/2010
1	Injections 01/2012
1	Sclerotherapy 01/2012
1	Liver Transplantation 05/2011
1	Oral Administration 03/2010